2018年9月毕业于华东理工大学药学院，获生物化学与分子生物学专业博士学位，随后进入华东理工大学药学流动站从事博士后研究工作。2022年12月出站留校工作，被聘为特聘副研究员。迄今以第一作者（含共一）发表于Cell Metabolism、PNAS、Nucleic Acids Research和Cell Reports，以共同作者在Science Advances、Nature Communications和The Journal of Clinical Investigation发表论文4篇，授权4项中国发明专利，公开9项国际PCT发明专利和11项中国发明专利。主持国自然青年科学基金项目、上海市自然科学基金面上项目和博士后基金面上项目，获得第十七届细胞生物学学会青年论坛技术创新奖。

（1）遗传编码荧光探针的开发与应用

（2）光遗传学技术的开发与应用

药学专业：硕士生导师

主要从事细胞代谢监测成像新技术的开发与应用。聚焦靶向各种疾病的代谢物，针对代谢物具有高度时空特异性，难以原位实时监测的难题，突破现有技术瓶颈，建立微生物高通量筛选与定向进化体系，基于此研发高性能乳酸荧光探针，绘制亚细胞乳酸代谢图谱，发现线粒体基质内富集高浓度乳酸，解决了该领域争议几十年的重要科学问题。建立基于探针的临床体液样本即时检测技术，发现尿液乳酸显著升高可能作为母系遗传性糖尿病的潜在筛查标志物，为临床诊断提供了重要依据；还创建过氧化氢探针和支链氨基酸探针，构建转基因动物，精确追踪活体内白血病细胞的氧化还原动态，助力白血病代谢研究，揭示氧化还原代谢在白血病生成中的重要作用与药物靶标。

1. Xie Li^#, Yinan Zhang^#, Lingyan Xu^#, Aoxue Wang^#, Yejun Zou^#, Ting Li^#, Li Huang^#, Weicai Chen^#, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang*, Joseph Loscalzo, Yi Yang* and Yuzheng Zhao*. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metabolism, 2023, 35(1), 200-211.

2. Xie Li, Changcheng Zhang, Xiaopei Xu, Jun Miao, Jing Yao, Renmei Liu, Yuzheng Zhao, Xianjun Chen* and Yi Yang*. A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells. Nucleic Acids Research, 2020, 48(6), e33.

3. Dan huang^#, Changcheng Zhang^#, Ming Xiao^#, Xie Li^#, Weicai Chen^#, Yu Jiang, Yamin Yuan, Yaping Zhang, Yejun Zou, Lei Deng, Yang Wang, Yuying Sun, Wenping Dong, Zhuo Zhang, Li Xie, Zhuo Yu, Chiqi Chen, Ligen Liu, Jing Wang, Yi Yang*, Jie Yang*, Yuzheng Zhao* and Junke Zheng*. Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells. PNAS, 2023, 120 (13), e2210796120.

4. Xiaoye Liu^#, Feifei Zhang^#, Yaping Zhang^#, Xie Li^#, Chiqi Chen^#, Meiyi Zhou, Zhuo Yu, Yunxia Liu, Yuzheng Zhao, Xiaoxin Hao, Yabin Tang, Liang Zhu, Ligen Liu, Li Xie, Hao Gu, Hongfang Shao, Fangzhen Xia, Chunrong Yin, Minfang Tao, Jingjing Xie, Cheng Cheng Zhang, Yi Yang, Haipeng Sun*, Guo-Qiang Chen*and Junke Zheng*. PPM1K regulates hematopoiesis and leukemogenesis through CDC20-mediated ubiquitination of MEIS1 and p21. Cell Reports, 2018, 23(5), 1461-1475.

5. Mengshu Jia^#, XiaoYue^#, Weixia Sun^#, Qianjun Zhou^#, ChengChang^#, Weihua Gong, Jian Feng, Xie Li, Ruonan Zhan, Kemin Mo, Lijuan Zhang, Yajie Qian, Yuying Sun, Aoxue Wang, YejunZou, Weicai Chen, Yan Li, Li Huang, Yi Yang*, Yuzheng Zhao*, Xiawei Cheng*. ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation. Science Advances, 2023, 9, eadg499.

6. Ting Li^#, Xianjun Chen^#, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye* and Yi Yang*. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nature Communications, 2021, 12, 615.

7. Xiaoxiao He^#, Jiangbo Wan^#, Xiaona Yang, Xiuze Zhang, Dan Huang, Xie Li, Yejun Zou, Chiqi Chen, Zhuo Yu, Li Xie, Yaping Zhang, Ligen Liu, Shangang Li, Yuzheng Zhao, Hongfang Shao*, Ye Yu* and Junke Zheng*. Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models. The Journal of Clinical Investigation, 2021, 131(4): e140242.

8. Kai Yang, Ming Wang, Yuzheng Zhao, Xuxu Sun, Yi Yang, Xie Li, Aiwu Zhou, Huilin Chu, Hu Zhou, Jianrong Xu, Mian Wu, Jie Yang* and Jing Yi*. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nature Communications, 2016, 7, 13599.